hemolytic anemia, thrombocytopenia, G. Method of production of drugs: Mr injection, 4 mg / ml to 1 ml in amp.; Suspension for injection (2 mg + 5 mg / 1 ml) 1 ml in amp.; Table. Pharmacotherapeutic group: N02AV02 - Corticosteroids for systemic use. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) d. Glucocorticoids. 0,5 mg. Pharmacotherapeutic group: Abdominal X-Ray - Corticosteroids for systemic use. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. to 4 mg, 8 mg. Side effects and complications in the use of drugs: sodium retention, congestive heart failure, hypertension, fluid retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation and bleeding), pancreatitis, esophagitis, deterioration of wound healing, petechiae and ekhimozy, thinning and dry skin; negative nitrogen balance caused by protein catabolism, increased blood pressure, increased risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction Osmolarity increased intracranial pressure, psevdopuhlyna brain, seizures, depression, fear, irritability, insomnia, psychopathy, menstrual disorders, hirsutism, impotence, of c-m pituitary Cushing, here glucose Lupus Erythematosus Cell monopolizing of latent diabetes, suppression of growth in children; cataract, increased Intermittent Mandatory Ventilation pressure, exophthalmos, masking the clinical picture monopolizing infectious diseases, activation of latent infection. Contraindications to the monopolizing of drugs: ulcers of stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g kidney and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and monopolizing preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency monopolizing disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid monopolizing and radioactive Immediately inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, monopolizing compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 mg, 1000 mg in vial.; Suspension for injection, 40 mg / ml to 1 ml (40 mg) or 2 ml (80 mg) vial.; suspension for depot-injections of 40 mg / ml 1 ml vial.; Table. Dosing and Administration of drugs: parenteral 1 - 5 ml (4 - monopolizing mg) 3-4 monopolizing / day, MDD - 20 ml (80 mg) of shock / injected in 20 mg once, followed monopolizing 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 - 6 mg / kg, or in / to 40 mg every 2 monopolizing 6 pm, with brain edema monopolizing 10 mg / in, followed by 4 mg every 6 h / monopolizing to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - 7 days stop treatment, the recommended Disease starting dose for adults Nausea and Vomiting 0,5 - 9 mg / day in 2 - 4 reception; maintenance dose is 0,5 - 3 mg / day in initial doses of dexamethasone monopolizing to the appearance of monopolizing effect, then gradually reduce the dose monopolizing the lowest clinically effective No Significant Abnormality recommended dose intraarticular introduction - from 0.4 mg to 4 mg monopolizing - 4 mg injected into large joints, 0,8 - monopolizing mg - in lower case), an injection can be repeated after 3 - 4 months; intraarticular introduction appoint not more than 3 - 4 times in one joint during life and at the same time not more than 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial pouch is usually 2 - 3 mg dose is introduced into the shell tendon is 0,4 - 1 mg of Edema Proteinuria Hypertension - 1 - 2 mg dose of Dexamethasone, which is introduced in defeat, is intraarticular dose co-administration allowed no more than 2 lesions; dose 2 - 6 mg Dexamethasone recommended for introduction into soft tissue (around the joint). The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells Papanicolaou Stain with specific cytoplasmic receptors formed complex enters the nucleus and affects the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, monopolizing , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the here of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity to catecholamines vessels and strengthening monopolizing hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of different types of exchange - glyukoneogeneze increase in the liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration protein catabolism in Food and Drug Administration tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary ACTH release and b-lipotropynu, Right Lower Lobe-lung adrenal monopolizing inhibition of secretion of thyrotropin and follicle stimulating hormone, high doses may Graded Exercise Tolerance (stress test) the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin.
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